HARMONY(R) EXTRA HERBICIDE Du Pont Agricultural Products M0000209 Revised: 19-JUN-1996 --------------------------------------------------------------------------- CHEMICAL PRODUCT/COMPANY IDENTIFICATION --------------------------------------------------------------------------- Material Identification "HARMONY" is a registered trademark of DuPont. Corporate MSDS Number: DU003065 Company Identification DU PONT 1007 Market Street Wilmington, DE 19898 PHONE NUMBERS Product Information:1-800-441-7515Transport Emergency: CHEMTREC:1-800-424-9300Medical Emergency:1-800-441-3637 --------------------------------------------------------------------------- COMPOSITION/INFORMATION ON INGREDIENTS --------------------------------------------------------------------------- Components Material CAS Number % --------------------------------------------- ----------------------------- Thifensulfuron Methyl 79277-27-3 50 (Methyl 3-[[[[(4-methoxy-6- methyl-1,3,5-triazin-2- yl)amino]carbonyl]amino]- sulfonyl]-2-thiophenecarboxylate) *Tribenuron Methyl 101200-48-0 25 (Methyl 2-[[[[N-(4-methoxy-5- methyl-1,3,5-triazin-2- yl)methylamino]carbonyl]amino]-sulfonyl]benzoate) Inert Ingredients 25 --------------------------------------------------------------------------- Disclosure as a toxic chemical is required under Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 and 40 CFR part 372. --------------------------------------------------------------------------- HAZARDS IDENTIFICATION --------------------------------------------------------------------------- Potential Health Effects CAUTION! Avoid contact with skin, eyes and clothing. ANIMAL DATA: Oral LD50: >5,000 mg/kg (rats) Very low toxicity. Dermal LD50: >2,000 mg/kg (rabbits) Low order of toxicity. SKIN IRRITATION AND SENSITIZATION: Animal tests on rabbits and guinea pigs indicate product is not a skin irritant nor a skin sensitizer. EYE IRRITATION: (Rabbits) Tests indicate product is a moderate irritant. Eyes were normal within 7 to 14 days. OTHER STUDIES-THIFENSULFURON METHYL Feeding Studies-No oncogenic effects observed in the 18-month mouse, 2-year rat, or 1-year dog feeding studies. Lower body weights and weight gains were observed for rats fed the highest dietary concentrations, 2,500 ppm. Slightly lower serum sodium concentrations, which were not biologically significant, were observed in rats fed the 500 and 2,500 ppm diets. The no-observable-effect levels (NOEL) were 500 ppm and 25 ppm for the body weight and serum sodium effects, respectively. There were no compound-related effects in mice fed for 18 months with diets that contained the active ingredient. The NOEL was 7,500 ppm, the highest dose tested. Slightly lower body weights and higher liver weights were observed for dogs fed for one year with diets that contained 7,500 ppm. There were no microscopic or functional changes associated with these effects. The NOEL was 750 ppm. Reproduction-No effect on rat reproduction or lactation at any dose tested (highest dose tested 2,500 ppm in the diet). There were no gross or microscopic compound-related effects on the offspring at any dose tested. Mutagenicity-Not mutagenic in the Ames bacterial assay; the in vitro Chinese Hamster Ovary assay; the in vitro unscheduled DNA synthesis; the in vivo cytogenetic assay; or in the mouse micronucleus assay. Teratogenicity-No teratogenic effects in rats at 800 mg/kg/day (highest dose tested), nor in rabbits at 650 mg/kg/day (highest dose tested). The no-observable-effect-level (NOEL), 200 ppm, was based on non-teratogenic effects at the higher doses. OTHER STUDIES-TRIBENURON METHYL 1-Year Feeding Study in Dogs-Dietary dose levels were 0, 25, 250, and 1,500 ppm A.I. There were no neoplastic or other histopathological effects associated with compound administration. The no-observable-effect-level (NOEL), 250 ppm (or 8.2 mg/kg body wt./day), was based on slightly lower body weights and increased serum creatinine concentrations for dogs in the high-dose group. 18-Month Feeding Study in Mice-Dietary dose levels were 0, 20, 200, and 1,500 ppm (A.I.). There were no neoplastic or other histopathological effects associated with compound administration. The NOEL, 200 ppm (or 30 mg/kg body wt./day), was based on lower body weights for mice in the high-dose group. 2-Year Feeding Study in Rats-Dietary dose levels were 0, 25, and 1,250 ppm (A.I.). Significantly lower body weights, which paralleled lower food consumption and organ weight effects, were observed in the 250 and 1,250 ppm groups. There were no clinical or histopathological abnormalities associated with these organ weight effects. The incidence of mammary adenocarcinomas was significantly greater for female rats in the 1,250 ppm group than for the controls. This effect was only observed in this high-dose group and under conditions of severe physiological stress (body weights for female rats were 42% lower than the controls.) Human exposures to this product resulting from the manufacture, agricultural use, or exposures via consumption of treated crops are expected to be tens of thousands times lower than that which produced tumors in female rats. Because of this and the following, this product is not expected to produce cancer in humans: the tumors were not reproducible in other laboratory studies; were produced only in a strain of rat predisposed to this tumor; occurred in animals under significant physiological stress; were produced at high lifetime exposures of 76 mg A.I./kg body wt./day or the equivalent of 18 grams "Harmony" Extra Herbicide/day for a 130 pound female; and this compound was not genotoxic or mutagenic. Teratogenicity Studies- (Rat, Rabbit) -The active ingredient did not produce birth defects after administering via oral intubation to pregnant rats (0, 20, 125, or 500 mg A.I./kg/day) and rabbits (0, 5, 20, or 80 mg A.I./kg/day). Maternal and fetal toxicity were observed at 125 and 500 mg/kg for the rat and at 80 mg/kg for the rabbit. The NOEL for both of these studies was 20 mg/kg/day based on lower food consumption, lower body weights for dams and fetuses, increased fetal mortality and other fetotoxic effects at the higher doses. Reproduction-(Rats)-There were no effects on fertility observed in a 2-generation reproduction study, in rats fed for at least 90 days with diets that contained 0, 25, 250, or 1,000 ppm A.I. The NOEL was 25 ppm based on lower body weights for the dams and offspring. Mutagenicity and Genotoxicity-The active ingredient was neither genotoxic nor mutagenic in five tests designed to assess these effects. Negative results were obtained in the following: Ames mutagenicity tests; in vitro cytogenetics test using Chinese Hamster Ovary cells; in vivo cytogenetics test using bone marrow cells from rats treated at 0, 50, 500 or 5,000 mg/kg body wt.; in vivo mouse micronucleus test; and a test to detect DNA damage in rat hepatocytes. Human Health Effects of Overexposure to Active Ingredients: Based on animal testing the following may occur: Overexposure to thifensulfuron methyl by skin contact may initially include skin irritation with discomfort or rash. Significant skin permeation, and systemic toxicity, after contact appears unlikely. There are no reports of human sensitization. Overexposure by eye contact may initially include eye irritation with discomfort, tearing, or blurring of vision. Overexposure by inhalation may initially include irritation of the upper respiratory passages, with coughing and discomfort. Overexposure to tribenuron methyl by prolonged skin contact may cause skin irritation with discomfort and rash. Repeated skin contact may cause allergic skin rashes. Overexposure by eye contact may initially include eye irritation with discomfort, tearing or blurring of vision. Carcinogenicity Information: None of the components present in this material at concentrations equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH as a carcinogen. --------------------------------------------------------------------------- FIRST AID MEASURES --------------------------------------------------------------------------- #FIRST AID Inhalation: No specific intervention is indicated as the compound is not likely to be hazardous by inhalation. Consult a physician if necessary. Skin Contact: In case of contact, wash skin with soap and water. Wash contaminated clothing before reuse. Eye Contact: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Call a physician. Ingestion: No specific intervention is indicated as compound is not likely to be hazardous by ingestion. Consult a physician if necessary. --------------------------------------------------------------------------- FIRE FIGHTING MEASURES --------------------------------------------------------------------------- Flammable Properties Flammable limits in Air, % by Volume: LEL: 0.173 g/L Autodecomposition: 305 C (581 F) Like most organic powders or crystals, under severe dusting conditions, this material may form explosive mixtures in air. Extinguishing Media: Water Spray, Foam, Dry Chemical, CO2. Fire Fighting Instructions: Wear self-contained breathing apparatus. Wear full protective equipment. Runoff from fire control may be a pollution hazard. --------------------------------------------------------------------------- ACCIDENTAL RELEASE MEASURES --------------------------------------------------------------------------- Safeguards (Personnel): NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL) sections before proceeding with cleanup. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during cleanup. Spill Cleanup: Shovel or sweep up. --------------------------------------------------------------------------- HANDLING AND STORAGE --------------------------------------------------------------------------- Handling (Personnel): Avoid contact with eyes, skin, or clothing. Wash thoroughly after handling. Wash clothing after use. Do not store or consume food, drink or tobacco in areas where they may become contaminated with this material. USERS SHOULD: Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. Storage: Do not store or consume food, drink or tobacco in areas where they may become contaminated with this material. --------------------------------------------------------------------------- EXPOSURE CONTROLS/PERSONAL PROTECTION --------------------------------------------------------------------------- Personal Protective Equipment Always follow label instructions when using this product. Applicators and other handlers must wear: Long-sleeved shirt and long pants Waterproof gloves Shoes plus socks Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is: Coveralls Waterproof gloves Shoes plus socks Exposure Guidelines Applicable Exposure Limits THIFENSULFURON METHYL PEL (OSHA): None Established TLV (ACGIH): None Established AEL * (Du Pont): 5 mg/m^3, 8 & 12 Hr. TWA TRIBENURON METHYL PEL (OSHA): None Established TLV (ACGIH): None Established AEL * (Du Pont): 1 mg/m^3, 8 Hr. TWA * AEL is Du Pont's Acceptable Exposure Limit. Where governmentally imposed occupational exposure limits which are lower than the AEL are in effect, such limits shall take precedence. --------------------------------------------------------------------------- PHYSICAL AND CHEMICAL PROPERTIES --------------------------------------------------------------------------- Physical Data Odor: Slightly pungent Form: Dry flowable Color: Slight beige Bulk Density (Loose): 0.59 g/mL --------------------------------------------------------------------------- STABILITY AND REACTIVITY --------------------------------------------------------------------------- Chemical Stability: Stable at normal temperatures and storage conditions. Incompatibility with Other Materials: None reasonably foreseeable. Decomposition: Decomposes slowly in water. Polymerization: Polymerization will not occur. --------------------------------------------------------------------------- ECOLOGICAL INFORMATION --------------------------------------------------------------------------- Ecotoxicological Information AQUATIC TOXICITY Thifensulfuron methyl and tribenuron methyl have low to slight toxicity. 96 hour LC50, rainbow trout: > 100 mg/L for both technicals 96 hour LC50, bluegill sunfish: > 100 mg/L for both technicals ENVIRONMENTAL TOXICITY LC50, mallard duck: > 5620 mg/kg for both technicals LC50, bobwhite quail: > 5620 mg/kg for both technicals --------------------------------------------------------------------------- DISPOSAL CONSIDERATIONS --------------------------------------------------------------------------- Waste Disposal: Treatment, storage, transportation, and disposal must be in accordance with applicable Federal, State/Provincial, and Local regulations. Do not flush to surface water or sanitary sewer system. Do not contaminate water, food or feed by storage or disposal. Waste resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. --------------------------------------------------------------------------- TRANSPORTATION INFORMATION --------------------------------------------------------------------------- Shipping Information DOT/IMO Proper Shipping Name: NOT REGULATED --------------------------------------------------------------------------- REGULATORY INFORMATION --------------------------------------------------------------------------- U.S. Federal Regulations TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312 Acute: Yes Chronic: No Fire: No Reactivity: No Pressure: No --------------------------------------------------------------------------- OTHER INFORMATION --------------------------------------------------------------------------- NFPA, NPCA-HMIS NFPA Rating Health: 1 Flammability: 1 Reactivity: 0 NPCA-HMIS Rating Health: 2 Flammability: 1 Reactivity: 0 Personal Protection rating to be supplied by user depending on use conditions. Additional Information REGULATORY CONTROLS "HARMONY" Extra Herbicide is regulated under EPA/FIFRA. EPA Reg. No.: 352-538. The data in this Material Safety Data Sheet relates only to the specific material designated herein and does not relate to use in combination with any other material or in any process. Responsibility for MSDS: Du Pont Address: Agricultural Products Wilmington, DE 19898 Telephone: 800-441-7515 # Indicates updated section.