MANZATE(R) 200 DF FUNGICIDE M0000207 Revised: 19-JUN-1996 --------------------------------------------------------------------------- CHEMICAL PRODUCT/COMPANY IDENTIFICATION --------------------------------------------------------------------------- Material Identification: "Manzate" is a registered trademark of DuPont. Corporate MSDS Number: DU005721 Company Identification DU PONT 1007 Market Street Wilmington, DE 19898 PHONE NUMBERS Product Information:1-800-441-7515Transport Emergency: CHEMTREC:1-800-424-9300Medical Emergency:1-800-441-3637 --------------------------------------------------------------------------- COMPOSITION/INFORMATION ON INGREDIENTS --------------------------------------------------------------------------- Components Material CAS Number % ------------------------------------------ --------------------------------- Mancozeb 8018-01-7 75 (A coordination product of zinc ion and manganese ethylene bisdithiocarbamate) Inert Ingredients 25 (Includes percentages of the following:) Paraformaldehyde 30525-89-4 > 1 ------------------------------------------ --------------------------------- --------------------------------------------------------------------------- HAZARDS IDENTIFICATION --------------------------------------------------------------------------- # Potential Health Effects CAUTION! May irritate eyes, nose, throat, and skin. May be harmful if absorbed through skin, inhaled, or swallowed. ANIMAL DATA: Acute Oral: LD50 > 5,000 mg/kg body wt. Very low toxicity by ingestion. Acute Dermal (rabbits): LD50 > 2,000 mg/kg. Slightly toxic by contact. Irritation: Not a primary skin irritant in test on rabbits. Eye: Produced mild to severe corneal opacity in rabbit eye tests. Eyes were normal within 7 days. CHRONIC STUDIES: MANCOZEB Inhalation: The effects in animals from repeated high doses of mancozeb (dust) equivalent to 150-250 times the AEL include reduced body weight, inflammation of the lungs, and abnormal thyroid function. Ingestion: Toxic effects in animals from repeated ingestion of high doses include reduced body weight and thyroid effects. Increased incidences of thyroid tumors and ocular lesions (retinopathy) were observed in rats administered 750 ppm (equivalent to approximately 35 mg/kg/day) of mancozeb in their diet for two years. This compound is considered to show weak carcinogenic activity. Tests in some animals indicate that the compound may produce embryo and fetal toxicity, but only at maternally toxic doses. Multigeneration studies in animals demonstrate no reproductive toxicity. Although there have been isolated reports in the scientific literature of mutagenic activity of mancozeb, in general mancozeb is not genotoxic in animals or in cell cultures. Mancozeb has not been tested for heritable gene mutation. Ethylenethiourea (ETU), a breakdown product and a minor metabolite of mancozeb, was shown to induce liver tumors in mice but not in rats or hamsters, and caused thyroid tumors in rats. ETU is not genotoxic. ETU has been categorized as a probable human carcinogen by IARC and as group B carcinogen by NTP. At sufficiently high doses ETU has also caused birth defects in laboratory animals. HUMAN HEALTH EFFECTS OF OVEREXPOSURE TO MANCOZEB: Overexposure to mancozeb by skin contact may initially include skin irritation with discomfort or rash. The compound has been infrequently associated with skin sensitization in humans. Significant skin permeation and systemic toxicity after contact appears unlikely. Eye contact may initially include eye irritation with discomfort, tearing, or blurring of vision. Based on animal studies, long-term exposure to high levels of mancozeb may cause abnormal thyroid function. Individuals with preexisting diseases of the thyroid may have increased susceptibility to the toxicity of excessive exposures. California (Proposition 65): This product contains mancozeb and ethylene thiourea, chemicals known to the state of California to cause cancer, birth defects, or other reproductive harm. Carcinogenicity Information: None of the components present in this material at concentrations equal to or greater than 0.1% are listed by IARC, NTP, OSHA, or ACGIH as a carcinogen. --------------------------------------------------------------------------- FIRST AID MEASURES --------------------------------------------------------------------------- First Aid INHALATION: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician. SKIN CONTACT: In case of contact, immediately wash skin with soap and water. Wash contaminated clothing before reuse. EYE CONTACT: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Call a physician. INGESTION: If swallowed, immediately give 2 glasses of water and induce vomiting. Never give anything by mouth to an unconscious person. Call a physician. --------------------------------------------------------------------------- FIRE FIGHTING MEASURES --------------------------------------------------------------------------- Flammable Properties Flammable limits in Air, % by Volume: LEL: 0.96 g/L Autoignition: 205C (401F) May be ignited by heat or open flame. Like most organic powders or crystals, under severe dusting conditions, this material may form explosive mixtures in air. Hazardous gases/vapors produced in fire are H2S, CS2, and oxides of sulfur, nitrogen, and carbon. Extinguishing Media: Water spray, foam, dry chemical, CO2. Fire Fighting Instructions: Keep personnel removed and upwind of fire. Wear self-contained breathing apparatus. Use water spray. Runoff from fire control may be a pollution hazard. If area is heavily exposed to fire and if conditions permit, let fire burn itself out since water may increase the contamination hazard. --------------------------------------------------------------------------- ACCIDENTAL RELEASE MEASURES --------------------------------------------------------------------------- Safeguards (Personnel): NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL) sections before proceeding with cleanup. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during cleanup. Initial Containment: Remove source of heat, sparks, flame, impact, friction, or electricity. Dike spill. Prevent material from entering sewers, waterways, or low areas. Spill Cleanup: Shovel or sweep up. Never return to container for reuse. Scoop into bags or boxes with plastic or aluminum shovel. --------------------------------------------------------------------------- HANDLING AND STORAGE --------------------------------------------------------------------------- Handling (Personnel): Avoid breathing vapors or mist. Avoid breathing dust. Avoid contact with eyes, skin, or clothing. Do not store or consume food, drink, or tobacco in areas where they may become contaminated with this material. Users Should: Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. Remove personal protective equipment immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. Handling (Physical Aspects): Avoid dust generation. Storage: Store in a well-ventilated place. Keep container tightly closed. Do not store or consume food, drink, or tobacco in areas where they may become contaminated with this material. --------------------------------------------------------------------------- EXPOSURE CONTROLS/PERSONAL PROTECTION --------------------------------------------------------------------------- Engineering Controls: Use only with adequate ventilation. Personal Protective Equipment: Always follow label instructions when using this product. Applicators and other handlers (other than mixers and loaders) must wear: Coveralls over long-sleeved shirt and pants Waterproof gloves Shoes plus socks Mixers and Loaders must wear: Coveralls over long-sleeved shirt and long pants Waterproof gloves Shoes plus socks Protective eyewear Chemical-resistant apron when mixing or loading Discard clothing or other absorbent materials that have been drenched or heavily contaminated with this product's concentrate. Do not reuse them. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is: Coveralls over long-sleeved shirt and long pants Waterproof gloves Shoes plus socks Exposure Guidelines Applicable Exposure Limits MANCOZEB PEL (OSHA): None established. TLV (ACGIH): None established. AEL * (DuPont): 2 mg/m^3, 8 Hr. TWA, total dust 1.5 mg/m^3, 12 Hr. TWA, total dust WEEL (AIHA): 1 mg/m^3, 8 Hr. TWA *AEL is DuPont's Acceptable Exposure Limit. Where governmentally imposed occupational exposure limits which are lower than the AEL are in effect, such limits shall take precedence. --------------------------------------------------------------------------- PHYSICAL AND CHEMICAL PROPERTIES --------------------------------------------------------------------------- Physical Data Solubility in Water: Dispersible. Odor: Sulfurous. Form: Solid. Color: Yellow. Bulk Density (Loose): 40-45 lbs/cu ft --------------------------------------------------------------------------- STABILITY AND REACTIVITY --------------------------------------------------------------------------- Chemical Stability: Stable at normal temperatures and storage conditions. Incompatibility with Other Materials: Incompatible with acids; moisture (in storage). Decomposition: Decomposes with heat. Hazardous gases/vapors produced are hydrogen sulfide, carbon disulfide, and oxides of carbon, nitrogen, and sulfur. Elevated temperature or free water promotes decomposition which may cause spontaneous combustion. Polymerization: Polymerization will not occur. --------------------------------------------------------------------------- ECOLOGICAL INFORMATION --------------------------------------------------------------------------- Ecotoxicological Information Aquatic Toxicity Mancozeb is toxic to fish: 96 hour, LC50 for Bluegill Sunfish: 1 ppm --------------------------------------------------------------------------- DISPOSAL CONSIDERATIONS --------------------------------------------------------------------------- Waste Disposal: Treatment, storage, transportation, and disposal must be in accordance with applicable Federal, State/Provincial, and local regulations. Do not flush to surface water or sanitary sewer system. Dispose of empty bag in a sanitary landfill or by incineration, or, if allowed by State and local authorities, by burning. If burned, stay out of smoke. --------------------------------------------------------------------------- TRANSPORTATION INFORMATION --------------------------------------------------------------------------- # Shipping Information DOT Proper Shipping Name: Not regulated by DOT. DOT/IMO Proper Shipping Name: MANEB PREPARATIONS, STABILIZED Hazard Class: 4.3 UN No.: UN 2968 Special Information: DANGEROUS WHEN WET Marine Pollutant: MARINE POLLUTANT (water or bulk) Packing Group: III --------------------------------------------------------------------------- REGULATORY INFORMATION --------------------------------------------------------------------------- U.S. Federal Regulations TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312 Acute: Yes. Chronic: Yes. Fire: No. Reactivity: Yes. Pressure: No. --------------------------------------------------------------------------- OTHER INFORMATION --------------------------------------------------------------------------- NFPA, NPCA-HMIS NFPA Rating Health: 1 Flammability: 1 Reactivity: 1 Water Reactive. NPCA-HMIS Rating Health: 2 Flammability: 1 Reactivity: 1 Personal Protection rating to be supplied by user depending on use conditions. Additional Information: Never allow product to become wet during storage. This may lead to chemical changes which will reduce the effectiveness as a fungicide and create flammable vapors. This product is registered and controlled under EPA/FIFRA regulations. EPA Reg. No.: 352-449 The data in this Material Safety Data Sheet relates only to the specific material designated herein and does not relate to use in combination with any other material or in any process. Responsibility for MSDS: DuPont Address: Agricultural Products Wilmington DE 19898 Telephone: 800-441-7515 # Indicates updated section.